Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

Meatloaf lovers should try my Italian Stuffed Meatloaf and Meatloaf with Stroganoff Sauce.

A spatula lifts a slice of meatloaf.

This post may contain affiliate links. Please read our disclosure policy.

Want to Save This Recipe?
Enter your email below, and we’ll send it straight to your inbox. Plus, get my best seasonal recipes each week!

Well, here we are just weeks away from Christmas and I’m talking about meatloaf today.

What does this recipe have to do with Christmas? Nothin’! But, it’s been chilly outside and when I’m cold my mind and my appetite turn towards comforting meals like this one.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

There is a lot going on with this meatloaf.

It starts with the typical mixture of ground beef and pork but then it takes a Tex-Mex fork in the road with the addition of chili sauce, onion, red bell pepper, diced green chilis, corn, and a bevy of seasonings to drive home the point.

Then, of course, I had to stuff it with shredded pepper Jack cheese and top it off with a tangy, smoky glaze.

Here’s how it comes together.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

Half of the meat mixture is placed in a baking dish that has been coated with non-stick cooking spray. I pressed it into a football shape and formed a well in the center.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

I filled the center with shredded pepper Jack cheese.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

Then, the other half of the meat mixture is molded down over the top, sealing the cheese inside.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

A two ingredient Smoky Chili Glaze is spread over the top towards the end of the baking time.

Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!

It’s a moist, tender meatloaf that would be wonderful served over a mound of mashed potatoes. This time around I served it with a mixture of roasted baby Yukon gold potatoes and sweet potatoes but this meatloaf would also be excellent served with Roasted Red Potatoes or Almond Rice Pilaf.

I highly recommend serving the leftovers on toasted hoagie rolls with more pepper Jack cheese melted over the top.

More meatloaf recipes you might enjoy:

Meatloaf with Stroganoff Sauce
Italian Sausage Market Meatloaf
Mini BBQ Meatloaves

Have you ever tried cooking meatloaf in your slow cooker? Check out this Crockpot Meatloaf. It’s a great method!

Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze

5 from 4 votes
Servings: 10
Prep Time: 15 minutes
Cook Time: 1 hour 5 minutes
Total Time: 1 hour 20 minutes
Big, bold, and flavorful, this Tex-Mex Cheese Stuffed Meatloaf with Smoky Chili Glaze will satisfy the heartiest of appetites!
Save this recipe!
Get this sent to your inbox, plus get new recipes from us every week!

Ingredients 

Meatloaf

  • 2 pounds ground beef
  • ½ pound ground bulk pork sausage, like Jimmy Deen’s Regular
  • ½ cup chili sauce
  • ¼ cup water
  • ¾ cup rolled oats
  • 1 egg, lightly beaten
  • 4 ounce can mild diced green chilis, drained
  • 1 tablespoon Worcestershire sauce
  • 1 tablespoon chili powder
  • 1 teaspoon cumin
  • 1 teaspoon garlic powder
  • 1 teaspoon dried oregano
  • ½ teaspoon freshly ground black pepper
  • 1 cup diced red bell pepper
  • 1 cup diced white or yellow onion
  • 1 cup frozen corn kernels, thawed
  • 1 ½ cups shredded pepper jack cheese

Smoky Chili Glaze

  • ¼ cup chili sauce
  • ½ teaspoon smoked paprika

Instructions 

  • Preheat the oven to 350 degrees F. Coat the bottom of a 13- x 9-inch or similar sized baking dish with nonstick cooking spray.
  • In a large mixing bowl, combine ½ cup of chili sauce with the water. Add the oats, egg, diced green chilis, Worcestershire, chili powder, cumin, garlic powder, oregano, and black pepper. Mix well. Add the ground beef, ground pork, bell pepper, onion and corn and mix well. Use your hands to work the mixture until all the ingredients are completely incorporated.
  • Divide the meat mixture in half. Lay half the meat mixture in the prepared baking dish, forming into a football shape. Create a shallow well so that the edges are higher than the center. Layer shredded cheese on top of the meat along the center, staying about ½-inch away from the edges. Cover completely with the 2nd half of the meat mixture forming a domed top and sealing the edges. Bake, uncovered, for 50 minutes.
  • Meanwhile, combine ¼ cup chili sauce with smoked paprika in a measuring cup or small bowl. After initial baking time, pull baking dish out of the oven and carefully spoon out and discard the excess grease from the dish. Spread the glaze over the top of the meatloaf and return to the oven to bake about 15 minutes longer, or until a meat thermometer inserted in the center of the meatloaf registers 165 degrees F. Allow the meatloaf to stand for 5 to½10 minutes before slicing.

Notes

Feel free to omit the ground pork and use 2 ½ pounds ground beef.
Chili sauce has a zesty, vinegary kick and can be found in the condiment section of your grocery store. For a milder flavor you can substitute plain tomato sauce.

Nutrition

Calories: 459kcal | Carbohydrates: 17g | Protein: 27g | Fat: 31g | Saturated Fat: 13g | Cholesterol: 114mg | Sodium: 670mg | Fiber: 3g | Sugar: 5g

Nutrition information is automatically calculated using generic ingredients, and is an estimate not a guarantee. For more accurate results, please refer to the labels on your ingredients at home.

VK logoLike this? Please rate & comment below!

Need Help With Menu Planning?

Sign up for my FREE email newsletter to receive my tried and true favorites + bonus seasonal content to keep you cooking through the year.

Looking for something else? Explore the Recipe Index →

Get my cookbook The Foolproof Family Slow Cooker!

About Valerie Brunmeier

Hello and welcome to my online kitchen! My focus here is to provide simple, seasonal meal solutions for busy households. I hope you find some inspiration while you’re here and visit again soon!

You May Also Like

5 from 4 votes (3 ratings without comment)

Leave a Review!

I love hearing from you! Submit your question or review below. Your email address will not be published. Required fields are marked*.

Recipe Rating




Questions & Reviews

  1. Rachel says:

    5 stars
    I’ve made this recipe several times & it has become a staple. Thank you!

  2. Nita says:

    How do I get this recipie without getting something called pintrest. I don’t wan that i just wan to be able to print this?

    1. Valerie says:

      The recipe card at the bottom of this post is printable.